WHAT CAN WE LEARN FROM the mutant mice about the possible link between neurosteroid Vitamin D and anxiety?
نویسنده
چکیده
В статье рассматриваются соб ственные и литературные данные о поведенческих дисфункциях у мы шей с нарушениями в системе ви тамина Д, вызванными мутацией ядерного рецептора (VDR) данного гормона. С использованием мето дов поведенческого фенотипирова ния и этологического анализа по казано, что мутация VDR приво дит к целостным поведенческим изменениям у мышей, подтверж дающим их тревожный поведен ческий профиль. В работе анали зируются поведенческие особенно сти мутантных мышей по гену VDR и обсуждается возможная роль нейростероидного гормона витамина Д в патогенезе тревожно сти у человека и животных.
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